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Course Code: 
PHAR 422
Course Period: 
Spring
Course Type: 
Core
P: 
2
Lab: 
0
Credits: 
2
ECTS: 
3
Course Language: 
English
Course Coordinator: 
Etil GÜZELMERİÇ
Courses given by: 
Etil GÜZELMERİÇ
Course Objectives: 
To provide information on fundamental concepts of pharmaceutical biotechnology and its application areas to undergraduate students.
Course Content: 

Introduction to biotechnology; the role of biotechnology in drug development and production, related basic concepts and applications;  isolation and purification of macromolecules;  nucleic acid amplification methods and their use in biotechnology; recombinant DNA technology and its applications in the field of pharmacy; hybridoma technology and monoclonal antibody production; antisense technology and applications; gene therapy and gene delivery systems; cell-based therapy; physicochemical properties of biopharmaceuticals and their formulation; microbial transformation techniques for the biosynthesis of corticosteroids, and their possible role in drugs development; plant tissue and organ culture techniques in the production of active drug substance; fermentation techniques and their applications in pharmaceutical industry; biologics, vaccines and serums.

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study
Course Evaluation Methods: 
A:Written exam, B: multiple chose , C:Filing the blank D:False and troth, E: Oral Exam F: Portfolio, G: contribution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Programme learning outcomes

Teaching Methods

Assessment Methods

1) Learn the main concepts and definitions in Biotechnology.

1, 2, 3, 4, 7, 9

1, 2, 3, 4

A, G, H

2) Instruct the importance and main application areas of Biotechnology in human life.

1, 2, 3, 4, 7, 9

1, 2, 3, 4

A, G, H

3) Teach the importance of Biotechnogy in Pharmaceutical practices.

1, 2, 3, 4, 7, 9

1, 2, 3, 4

A, G, H

4) Instruct the pharmaceutical applications of Gen therapy, Recombinant DNA technology etc. 

1, 2, 3, 4, 7, 9

1, 2, 3, 4

A, G, H

5) Instruct the monoclonal antibodies, PCR, blotting techniques, production techniques of vaccines.

1, 2, 3, 4, 7, 9

1, 2, 3, 4

A, G, H
 

Course Flow

COURSE CONTENT (IN DETAIL)

Week

Topics

Study Materials

1

Introduction to biotechnology

Lecture notes

2

Applications of biotechnology, introduction to pharmaceutical biotechnology, biosafety

Lecture notes

3

Cell macromolecules, disruption of cells and purification of macromolecules with chromatographic techniques

Lecture notes

4

Introduction to PCR (Polymerase Chain Reaction), Steps in PCR, Real Time PCR, Applications of PCR and real time PCR

Lecture notes

5

Gel Electrophoresis, Southern, Northern and Western Blotting and Elisa Techniques

Lecture notes

6

Monoclonal Antibodies

Lecture notes

7

Midterm

Lecture notes

8

Plant cell/tissue culture techniques and applications in drugs production

Lecture notes

9

Fermentation technology, main concepts, definitions, application areas

Lecture notes

10

Biologics and Immunomodulators (Vaccines and Sera)

Lecture notes

11

Microbiological transformation

Lecture notes

12

Student Presentations

Scientific papers

13

Student Presentations

Scientific papers

14

Student Presentations

Scientific papers
 

Recommended Sources

RECOMMENDED SOURCES (REFERENCES)

Textbook

1. Michael J. Groves. Pharmaceutical Biotechnology, Second Edition, CRC Press Taylor & Francis Group, 2006.

2. Gary Walsh. Biopharmaceuticals : biochemistry and biotechnology, Second Edition, J. Wiley , 2003.

3. Lecture Notes

Additional Resources

 
 

Material Sharing

MATERIAL SHARING

Documents

Lecture notes

Assignments

Shareable

Exams

Not shareable
 
 
 

Assessment

ASSESSMENT

IN-TERM STUDIES

NUMBER

PERCENTAGE

Mid-terms

1

80

Quiz(zes)

0

0

Assignment

2

20

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

60

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

40

Total

 

100
 

 

COURSE CATEGORY

Undergraduate Courses
 

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM

No

Program Learning Outcomes

Contribution

1

2

3

4

5

PO.1

Has national and international up-to-date, theoretical and applied knowledge in the field of pharmacy.

 

 

 

 

X

PO.2

Defines problems related to the profession, collects data, evaluates its accuracy and reliability, develops evidence-based solutions, shares them with healthcare professionals, makes necessary explanations to other people.

 

 

 

 

X

PO.3

Communicates accurately and effectively in accordance with cultural and ethical values with all relevant professional groups, especially those working in the field of health, and all segments of society, using information and communication technologies.

 

 

 

 

X

PO.4

Takes into account the law and ethics when dealing with public health issues.

 

 

 

 

X

PO.5

Acts as a pharmacist with high career awareness, self-confidence, leadership spirit, who is prone to teamwork, entrepreneurial, productive and able to manage financial resources.

 

 

 

X

 

PO.6

Based on the principle of pharmaceutical care, Acts as an easily accessible health consultant with a patient-oriented approach and plays an active role in constantly informing the society.

 

X

 

 

 

PO.7

Improves his/her knowledge by participating in in-service training and activities in line with the needs of the century and society, takes part in the professional development of colleagues and adopts the lifelong learning principle.

 

 

 

 

X

PO.8

Suggests and manages multidisciplinary / interdisciplinary research and development projects related to pharmaceuticals, cosmetics, medical devices and shares their results.

 

 

 

X

 

PO.9

Applies knowledge and skills for the benefits of the society taking part in social responsibility projects.

 

 

 

 

X

PO.10

Fulfills the requirements of quality management systems using the theoretical and applied knowledge acquired in the field.

X

 

 

 

 
 
 

ECTS

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

15

2

30

Hours for off-the-classroom study (Pre-study, practice)

15

2

30

Midterm Exams

1

1

1

Lab. Applications

-

-

-

Hours for off-the-Lab. study (Pre-study, practice)

-

-

-

Lab. Midterm Exam

-

-

-

Lab. Final

-

-

-

Homework

1

12

12

Final

1

2

2

Total Work Load

 

 

75

Total Work Load / 25 (h)

 

 

3

ECTS Credit of the Course

 

 

3
 
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