• Türkçe
  • English
Course Code: 
PHAR 311
Course Period: 
Autumn
Course Type: 
Core
P: 
4
Lab: 
4
Credits: 
4
ECTS: 
6
Course Language: 
English
Course Objectives: 
The aim of this course is to teach the synthesis, analysis, metabolism, mechanism of action and structure activity relationships of pharmacologycally active synthetic drugs and also identification of organic compounds
Course Content: 

 

a)Therotical part

The main aim of these lectures is to confer to pharmacy students a theoretical knowledge on Autonomic nervous system, analeptics, introduction to central nervous system drugs, sedatives and hypnotics, local anesthetics and general anesthetics drugs effecting seratonine receptors, antiperkinsonian agents, Psychotherapeutic drugs, tranquillizans, anticonvulsant drugs, antihistaminic, NSAIA and opioid Analgesic, Antihistaminic Drugs, antiulcer agents.

b)Laboratory applications

The main aim of these practical lectures is to equip pharmacy students with functional group analysis. Qualitative analysis of drugs with conventional and spectral methods such as UV, IR, H-NMR, Mass and structure elucidation.The laboratory applications will focus on many techniques used for functional group analysis, and identification of organic compounds by using UV, IR, H-NMR, Mass and elementary analysis. It is mandatory to pass the final exam of practical lectures in order to qualify for entering the final exam of theoretical part of this class.

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 9: Simulation, 12: Case Study
Course Evaluation Methods: 
A: Testing, C: Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Teaching Methods

Assessment Methods

 The student should be able to know

1)Names of the compounds according to IUPAC system

1,2,3

A,C

2) Knows synthesis of some compounds

1,2,3

A,C

3) Predicts biotransformation of the compounds.

1,2,3

A,C

4) Knows mechanism of action of compounds and pharmacologycal activity

1,2,3

A,C

5) Elucidates spectral identification of organic compounds.

1,2,3

A,C

6) Knows SAR studies.

1,2,3

A,C

 
 

Course Flow

Week

Teorical Topics/                                      Lab content

Study Materials

1

Drugs effecting parasympathic system/Laboratory Demonstration: Qualitative Organic Analysis

 

2

Sympathomimetics drugs /Identification of functional groups in conventional experiments

 

3

Psychotherapeutic drugs      Qualitative Analysis of Known Compound

 

4

Opioid analgesic          /      Qualitative Analysis of Known Compound

 

5

Local anesthetıcs

 and Volatile ansthetics / Qualitative Analysis of Known Compound

 

6

Cardiac glycosides, antianginal,     / Qualitative Analysis of Unknown Compound
 

 

7

antiarrhythmic drugs         / Qualitative Analysis of Unknown Compound
 

 

8

Diuretics and  Angiotensin converting enzyme inhibitors (antagonists)/ Lab. Mid-term

 

9

Mid Term I                                /    Demonstration of UV spectrometre

 

10

Antihyperlipoprotenemics and cholesterol biosynthesis  / Principle of                     Infrared Spectroscopy

 

11

  Antiplatelet drugs   /  Infrared Spectroscopy Analysis of Acetaminophen

 

12

Antithrombotics, thrombolytics and coagulant agents     /    Laboratory Demonstration: 1H NMR Spectroscopy

 

13

Mid term II  / Laboratory Demonstration: 13C -NMR Spectroscopy

 

14

 Drugs affecting the ımmune systems

Nonsteroidal anti-inflammatory agents  / Laboratory Demonstration: Mass Spectrometry  

 

15

 Antihistamines and related antiallergic agents   /case studies

 

16

Antiulcer drugs         /  Spectral demostration of   unkown compounds

 
 
 

Recommended Sources

Textbook

Course Slayts of Prof. Dr. Hülya Akgün

Additional Resources

1. David A. Williams, Thomas L. Lemke ‘Foye’s Principle of medicinal Chemistry’ 8th edition, Williams & Wilkins, Phyladelphia(2007)

2. H.Akgün, A. Balkan, A.Bilgin, Ü. Çalış, N. Gökhan, S. Dalkara, H. Erdoğan, D. Demir, M. Ertan, F. Özkanlı, E. Palaska, S. Saraç, C. Şafak, B. Tozkoparan, ‘Farmasötik Kimya’ İkinci baskı, Hacettepe, Ankara (2004)

3. John H. Block, John M. Beale Jr., ‘Wilson and Giswolds textbook of organic madicinal and pharmaceutical chemistry’ 11th edition, Baltimore Williams & Wilkins, (2004).

 4.Spectrometric Identification of Organic Compounds (7th Edition)

Silverstein, Robert M.; Webster, Francis X.; Kiemle, David J. © 2005 John Wiley & Sons

 

 

 
 

Material Sharing

Documents

Course Slayts

Assignments

Spectrum analysis of the compounds

Exams

 
 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Midterm  Exam I

1

30

Midterm Exam II

2

30

Lab.

1

40

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

40

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

60

Total

 

100

 

 

COURSE CATEGORY

Expertise/Field Courses

 
 

Course’s Contribution to Program

No

Program Learning Outcomes

Contribution

1

2

3

4

5

1

To educate students about chemistry and pharmacology of the drugs effecting  central nervous system

     

X

 

2

To get learn chemistry and pharmacology of opioid analgesics

     

X

 

3

To get learn chemistry and pharmacology of cardiac glycosides, antianginal and antiarrhythmic drugs

     

X

 

4

To get learn chemistry and pharmacology of diuretics and  Angiotensin converting enzyme inhibitors (antagonists).

     

X

 

5

To get learn chemistry and pharmacology of antihyperlipoprotenemics and cholesterol biosynthesis and antiplatelet drugs

         

6

To get learn chemistry and pharmacology of antithrombotics, thrombolytics and coagulant agents

     

X

 

7

To gain knowledge of drugs affectıng the ımmune systems such as nonsteroidal anti-inflammatory agents Antihistamines and related antiallergic agents and  antiulcer drugs

     

X

 

8

To predict molecular structure from corresponding spectral methods

     

X

 
 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

16

4

64

Hours for off-the-classroom study (Pre-study, practice)

2

1

1

Midterm Exams

2

1

2

Lab. Applications

16

4

64

Hours for off-the-Lab. study (Pre-study, practice)

16

0.5

8

Lab. Midterm Exem

1

1

1

Lab. Final

1

2

2

Homework

1

2

2

Final

1

2

2

Total Work Load

 

 

146

Total Work Load / 25 (h)

 

 

5.84

ECTS Credit of the Course

 

 

6