Pharmaceutical Chemistry I+Lab.I

Course Code:

PHAR 212

Course Period:

Spring

Course Type:

Core

P:

4

Lab:

0

Credits:

6

ECTS:

6

Prerequisite Courses:

Organic Chemistry II+Lab.II

Course Language:

English

Course Coordinator:

Hülya AKGÜN

Courses given by:

Hülya AKGÜN

Meriç KÖKSAL AKKOÇ

Filiz Esra ÖNEN BAYRAM

Course Objectives:

The aim of this course is to teach the Principle of medicinal chemistry and synthesis, analysis, metabolism, mechanism of action and structure activity relationships of pharmacologically active synthetic drugs and also identification of organic compounds.

Course Content:

a) Therotical part

The main aim of these lectures is to confer to pharmacy students a knowledge on principles of medicinal chemistry, physico-chemical properties of drugs related to biologic activity, receptor and drug receptor interaction, structural features and pharmacologic activity, thereotical aspect of drug design, drug metabolism chemo-therapeutic agents, antibiotics and synthetic antibacterials, synthetic antimicrobial agent, antiparasitic agents, antiviral agents and protease inhibitors, antifungal drugs and cancer and cancer chemotherapy .

b) Laboratory applications

The main aim of these practical lectures is to equip pharmacy students with Density Determination, Refractometry, Polarimetry, Pharmacopoeia Analysis, High Pressure Liquid Chromatography and Ultraviolet Spectroscopy.

Course Methodology:

1: Lecture, 2: Question-Answer, 3: Discussion,

Course Evaluation Methods:

A: Testing, C: Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes	Programme learning outcomes	Teaching Methods	Assessment Methods
1)The student should be able to know principles of medicinal chemistry		1,2,3	A,C
2)Names of the compounds according to IUPAC system		1,2,3	A,C
3) Knows synthesis of some compounds		1,2,3	A,C
4) Knows biotransformation of the compounds.		1,2,3	A,C
5) Explains mechanism of action of compounds and pharmacologycal activity		1,2,3	A,C
6) Knows spectral identification of organic compounds.		1,2,3	A,C

Course Flow

COURSE CONTENT
Week	Teorical Topics	Lab. content	Study Materials
1	Principles of medicinal chemistry	Lab Demonstration
2	Physical- chemical properties of drugs related to biologic activity	Lab. Demonstration
3	Receptor and drug receptor interaction	Density determination
4	Structural features and pharmacologic activity	Refractometry
5	Drug metabolism	Polarimetry
6	Drug metabolism	Pharmacopeiae analysis
7	Chemotherapeutic agents	Midterm
8	Antibiotics and synthetic antibacterials	Lab. Demonstration
9	Midterm 1	Lab. Demonstration
10	Synthetic antimicrobial agent	HPLC
11	Antiparasitic agents	HPLC
12	Antiviral agents and protease inhibitors	UV spectrometry
13	Antifungal Drugs	Colorimetry
14	Midterm2	Problem solving
15	Cancer and cancer chemotherapy	Problem solving

Recommended Sources

RECOMMENDED SOURCES

Textbook

Course Slayts of Prof. Dr. Hülya Akgün

Additional Resources

1. David A. Williams, Thomas L. Lemke ‘Foye’s Principle of medicinal Chemistry’ 8^thedition, Williams & Wilkins, Phyladelphia(2007)

2. H.Akgün, A. Balkan, A.Bilgin, Ü. Çalış, N. Gökhan, S. Dalkara, H. Erdoğan, D. Demir, M. Ertan, F. Özkanlı, E. Palaska, S. Saraç, C. Şafak, B. Tozkoparan, ‘Farmasötik Kimya’ İkinci baskı, Hacettepe, Ankara (2004)

3. John H. Block, John M. Beale Jr., ‘Wilson and Giswolds textbook of organic madicinal and pharmaceutical chemistry’ 11^th edition, Baltimore Williams & Wilkins, (2004)

4.Spectrometric Identification of Organic Compounds (7th Edition)Silverstein, Robert M.; Webster, Francis X.; Kiemle, David J. 2005 John Wiley & Sons

5.Thomas L. Lemke, S. William Zito, Victoria F. Roch and DavidA.Williams Çeviri Editörleri: Prof Dr. Öztekin Algül, Dr. Ecz. KayhanBolelli, Foye Medisinal Kimya Temel İlkeleri 2019.

Material Sharing

MATERIAL SHARING
Documents	Course Slayts
Assignments
Exams

Assessment

ASSESSMENT
IN-TERM STUDIES	NUMBER	PERCENTAGE
Mid-term I	1	30
Mid-Term II	2	30
Lab.	1	40
Total		100
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE		40
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE		60
Total		100

COURSE CATEGORY

Expertise/Field Courses

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM
No	Program Learning Outcomes	Contribution
No	Program Learning Outcomes	1	2	3	4	5
1	Has national and international up-to-date, theoretical and applied knowledge in the field of pharmacy.				X
2	Defines problems related to the profession, collects data, evaluates its accuracy and reliability, develops evidence-based solutions, shares them with healthcare professionals, makes necessary explanations to other people.			X
3	Communicates accurately and effectively in accordance with cultural and ethical values with all relevant professional groups, especially those working in the field of health, and all segments of society, using information and communication technologies.
4	Takes into account the law and ethics when dealing with public health issues.
5	Acts as a pharmacist with high career awareness, self-confidence, leadership spirit, who is prone to teamwork, entrepreneurial, productive and able to manage financial resources.
6	Based on the principle of pharmaceutical care, Acts as an easily accessible health consultant with a patient-oriented approach and plays an active role in constantly informing the society.	x
7	Improves his/her knowledge by participating in in-service training and activities in line with the needs of the century and society, takes part in the professional development of colleagues and adopts the lifelong learning principle.		X
8	Suggests and manages multidisciplinary / interdisciplinary research and development projects related to pharmaceuticals, cosmetics, medical devices and shares their results.				X
9	Applies knowledge and skills for the benefits of the society taking part in social responsibility projects.
10	Fulfills the requirements of quality management systems using the theoretical and applied knowledge acquired in the field.			X

ECTS

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Course Duration (Including the exam week: 15x Total course hours)	15	4	60
Hours for off-the-classroom study (Pre-study, practice)	15	0.5	7.5
Mid-terms	2	4	8
Lab. Applications	15	4	60
Hours for off-the-Lab. study (Pre-study, practice)	15	0.5	7.5
Lab. Mid-term	1	2	2
Lab. Final	1	3	3
Homework	1	1	1
Final	1	10	10
Total Work Load			159
Total Work Load / 25 (h)			6.36
ECTS Credit of the Course			6

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