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Course Code: 
PHAR 212
Course Period: 
Spring
Course Type: 
Core
P: 
4
Lab: 
4
Credits: 
4
ECTS: 
6
Course Language: 
English
Course Objectives: 
The aim of this course is to teach the Principle of medicinal chemistry and synthesis, analysis, metabolism, mechanism of action and structure activity relationships of pharmacologically active synthetic drugs and also identification of organic compounds.
Course Content: 

a)Therotical part

The main aim of these lectures is to confer to pharmacy students a knowledge on principles of medicinal chemistry,  physico-chemical properties of drugs related to biologic activity, receptor and drug receptor interaction, structural features and pharmacologic activity,  thereotical aspect of drug design, drug metabolism chemo-therapeutic agents, antibiotics and synthetic antibacterials, synthetic antimicrobial agent, antiparasitic agents, antiviral agents and protease inhibitors, antifungal drugs and cancer and cancer chemotherapy .

b)Laboratory applications

The main aim of these practical lectures is to equip pharmacy students with Density Determination, Refractometry, Polarimetry, Pharmacopoeia Analysis, High Pressure Liquid Chromatography and Ultraviolet Spectroscopy.

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 9: Simulation, 12: Case Study
Course Evaluation Methods: 
A: Testing, C: Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Teaching Methods

Assessment Methods

 1)The student should be able to know

principles of medicinal chemistry

1,2,3

A,C

2)Names of the compounds according to IUPAC system

1,2,3

A,C

3) Knows synthesis of some compounds

1,2,3

A,C

4) Knows biotransformation of the compounds.

1,2,3

A,C

5) Explains mechanism of action of compounds and pharmacologycal activity

1,2,3

A,C

6) Knows spectral identification of organic compounds.

1,2,3

A,C

     
 
 

Course Flow

Week

Teorical Topics

Lab. content

Study Materials

1

Principles of medicinal chemistry 

Lab Demonstration

 

2

Physical- chemical properties of drugs related to biologic activity 

PHAR 212

                                                 

Lab. Demonstration

 

3

Receptor and drug receptor interaction         

Density determination

 

4

Structural features and pharmacologic activity 

Refractometry

 

5

Thereotical Aspect of Drug Design

Polarimetry

 

6

Drug metabolism                                                              

Pharmacopeiae analysis

 

7

Chemotherapeutic agents                                            

Midterm

 

8

Antibiotics and synthetic antibacterials              

Lab. Demonstration

 

9

Midterm 1

Lab. Demonstration

 

10

Synthetic antimicrobial agent                                    

HPLC

 

11

Antiparasitic agents                                                  

HPLC

 

12

Antiviral agents and protease inhibitors                  

UV spectrometry

 

13

Antifungal Drugs

Colorimetry

 

14

Midterm2

Interpretation

 

15

Cancer and cancer chemotherapy                           

General revision

 

16

Discussion and Case study

   
 
 

Recommended Sources

Textbook

Course Slayts of Prof. Dr. Hülya Akgün

Additional Resources

1. David A. Williams, Thomas L. Lemke ‘Foye’s Principle of medicinal Chemistry’ 8th edition, Williams & Wilkins, Phyladelphia(2007)

2. H.Akgün, A. Balkan, A.Bilgin, Ü. Çalış, N. Gökhan, S. Dalkara, H. Erdoğan, D. Demir, M. Ertan, F. Özkanlı, E. Palaska, S. Saraç, C. Şafak, B. Tozkoparan, ‘Farmasötik Kimya’ İkinci baskı, Hacettepe, Ankara (2004)

3. John H. Block, John M. Beale Jr., ‘Wilson and Giswolds textbook of organic madicinal and pharmaceutical chemistry’ 11th edition, Baltimore Williams & Wilkins, (2004)

 4.Spectrometric Identification of Organic Compounds (7th Edition)

Silverstein, Robert M.; Webster, Francis X.; Kiemle, David J. © 2005 John Wiley & Sons

 

 

 
 

Material Sharing

Documents

Course Slayts

Assignments

 

Exams

 
 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Mid-term I

1

30

Mid-Term II

2

30

Lab.

1

40

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

40

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

60

Total

 

100

 

 

COURSE CATEGORY

Expertise/Field Courses

 
 

Course’s Contribution to Program

No

Program Learning Outcomes

Contribution

1

2

3

4

5

1

To educate students about principles of Medicinal Chemistry and history

     

X

 

2

To get learn   physico-chemical properties of drugs related to biologic activity

     

X

 

3

Knows receptor and drug receptor interaction, structural features and pharmacologic activity,  thereotical aspect of drug design

     

X

 

4

To get learn drug metabolism

     

X

 

5

To get learn chemistry and pharmacology of chemo-therapeutic agents, antibiotics and synthetic antibacterials, synthetic antimicrobial agent, antiparasitic agents, antiviral agents and protease inhibitors, antifungal drugs

     

X

 

6

To get learn chemistry and pharmacology of and cancer and cancer chemotherapy .

     

X

 
 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

16

4

64

Hours for off-the-classroom study (Pre-study, practice)

2

1

1

Mid-terms

2

1

2

Lab. Applications

16

4

64

Hours for off-the-Lab. study (Pre-study, practice)

16

0.5

8

Lab. Mid-term

1

1

1

Lab. Final

1

2

2

Homework

1

2

2

Final

1

2

2

Total Work Load

 

 

146

Total Work Load / 25 (h)

 

 

5.84

ECTS Credit of the Course

 

 

6