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Course Code: 
PHAR 213
Course Period: 
Autumn
Course Type: 
Core
P: 
4
Lab: 
3
Credits: 
4
ECTS: 
6
Course Language: 
Turkish
Course Objectives: 
The main aim of these lectures is to provide students a strong tool that will be used to understand at a molecular level reactions occurring in biological systems. As a continuation of PHAR 114 Organic Chemistry I, the lectures will focus on the main organic functions encountered in biological systems. For each functionality their nomenclature, their physico-chemical properties and major chemical reactions associated with each family will be described.
Course Content: 

 

a) Theoretical Part:

 

Chemistry of Benzene: Electrophilic Aromatic Substitution; Alcohols and Phenols; Ethers and Epoxides; Thiols and Sulfides; Carbonyl Compounds; Carboxylic Acids and Nitriles; Carboxylic Acid Derivatives; Amines; Biomolecules-Carbonhydrates; Biomolecules-Aminoacids; Biomolecules-Lipids; Heterocycles and Nucleic Acids

 

b) Laboratory Practice:

 

Laboratory safety demonstration; Basic organic laboratory skills demonstration; Glassware demonstration; Yield calculation demonstration; Thin layer chromatography demonstration; Iodoform and Dermatole synthesis; Aspirin synthesis; Acetophenone synthesis; Acetanilide synthesis; Benzoin synthesis; Benzil synthesis; Diphenylhydantoin synthesis; Benzoic acid and Benzyl alcohol synthesis

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study
Course Evaluation Methods: 
A:Written exam, B: multiple chose , C:Filing the blank D:False and troth, E: Oral Exam F: Portfolio, G: Contrabution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Programme learning outcomes

Teaching Methods

Assessment Methods

1) Names compounds based on IUPAC nomenclature.

7, 14

1,2,3

A,C

2) Knows synthesis of organic compounds.

7, 14

1,2,3

A,C

3) Knows reactions of organic compounds.

7, 14

1,2,3

A,C

4) Knows physicochemical properties of organic compounds.

7, 14

1,2,3

A,C

5) Can synthesize organic compounds in laboratory.

7, 14

1,2,3

A,C

6) Knows various methods to isolate compounds from reaction environment.

7, 14

1,2,3

A,C

7) Knows various methods to purify compounds after isolation.

7, 14

1,2,3

A,C

8) Knows purity analysis methods suchs as melting point determination and thin kayer chromatography.

7, 14

1,2,3

A,C

9) Knows percentage yield calculation of purified compounds.

7, 14

1,2,3

A,C

 
 

Course Flow

Week

Teorical Topics                                     

Lab content

Study Materials

1

Chemistry of Benzene: Electrophilic Aromatic Substitution

Laboratory safety; Basic organic laboratory skills; Glassware demonstration

 

2

Alcohols and Phenols

Yield calculation; Thin layer chromatography demonstration

 

3

Ethers and Epoxides

Iodoform and Dermatole synthesis

 

4

Thiols and Sulfides

Aspirin synthesis

 

5

Carbonyl Compounds

Acetophenone synthesis

 

6

Carboxylic Acids and Nitriles

Acetanilide synthesis

 

7

Carboxylic Acid Derivatives

Midterm

 

8

Amines

Benzoin synthesis

 

9

Midterm I

Benzil synthesis

 

10

Biomolecules-Carbonhydrates

Diphenylhydantoin synthesis

 

11

Biomolecules-Aminoacids

Benzoic acid and Benzyl alcohol synthesis

 

12

Biomolecules-Lipids

Make-up week

 

13

Heterocycles and Nucleic Acids

Problem solvation

 

14

Midterm II

Problem solvation

 

15

Summary and Discussion

Problem solvation

 
 
 

Recommended Sources

Textbook

Prof. Dr. Mine Yarım Yüksel and Doç. Dr. Meriç Köksal Akkoç lecture notes

Additional Resources

1. John McMurry,Organic Chemistry, 6th Ed, Thomson Brooks/Cole, USA (2004)

2. Solomons G., Fryhe J., Solomons Organic Chemistry, 10th Ed, Wiley, USA (2010)

 
 

Material Sharing

Documents

Photocopy

Assignments

 

Exams

 
 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Midterm  Exam

2

60

Short Exam

   

Lab.

15

20

Lab final

1

20

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 1

40

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 1

60

Total

 

100

 

 

COURSE CATEGORY

Compulsary/Elective

 
 

Course’s Contribution to Program

No

Program Learning Outcomes

Contribution

1

2

3

4

5

1

Acquire skills needed to practice the profession of pharmacy in either a Turkish or an English language setting.

 

X

     

2

Being equipped to access current theoretical and applied knowledge, keeping abreast of new developments, and possessing the critical faculties enabling an accurate and reliable interpretation and assessment of this information.

 

X

     

3

Having the capacity to apply the skills acquired in the field of pharmaceutical science. Possessing the ability to harness his/her acquired knowledge in order to function as a highly accessible health counsellor, providing a ready source of clinically relevant, health-related information to the general public.

 

X

     

4

Keeping abreast of and being equipped to apply the fundamental pharmaceutical and health science principles which guide future developments in modern technology, and being able to share these experiences and skills with colleagues through participatation in professional development education seminars.

   

X

   

5

Knowing how to assess risks arising from the use of drugs and other chemicals and those risks potentially encounterd during laboratory practice.

   

X

   

6

Acquiring the skills and knowledge needed to interpret findings obtained through quantative and qualitative measurements, and thus reach valid, scientific conclusions based on this data. 

   

X

   

7

Being able to compound pharmaceutical products while being knowledgable about their clinical application, interactions, side effects and risks  and apply in proper manner .

     

X

 

8

Being competent to conduct and manage research and development projects, and share experimental outcomes.

X

       

9

Be competent to accurately and intelligibly communicate clincally relevant information to patients concerning prescription items and other pharmaceutical products.  

 

X

     

10

Being able to function in a multidisciplinary environment. Possessing the skill to collaborate and establish lines of communication with other professionals, while developing their own professional competency through participation in relevant continuing education activities.

 

X

     

11

Being able to play a role in projects which fulfills the profession’s societal responsibilities. Participating in professional activities and undertaking duties in a manner which reflects an awareness of and sensitivity to environmental issues.

   

X

   

12

Being capable of opening a community pharmacy, practicing in a hospital pharmacy setting, and offering service in any field related to drugs, cosmetics, medical  and/or plant-derived products. Able to play an active role in his/her own personal professional development, as well as that of colleagues and pharmaceutical students.

   

X

   

13

Able to play a role in issues related to public health as a member of the health care team while being cognizant of and able to fulfill legal and professional requirements and maintain ethical standards. 

   

X

   

14

Is knowledgable of and equipped to manage the planning, development, compounding and quality control analysis of naturally occuring and synthetic medicines, while also being aware of the processes related to these products’ absorption, distribution, metabolism and excretion from the body.

       

X

 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

16

4

64

Hours for off-the-classroom study (Pre-study, practice)

8

0.5

4

Midterm Exams

2

4

8

Lab. Applications

16

4

64

Hours for off-the-Lab. study (Pre-study, practice)

4

0.5

2

Lab. Midterm Exem

1

2

2

Lab. Final

1

4

4

Homework

     

Final

1

4

4

Total Work Load

 

 

152

Total Work Load / 25 (h)

 

 

6.08

ECTS Credit of the Course

 

 

6