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Course Code: 
PHAR 575
Course Type: 
Elective
P: 
2
Lab: 
0
Credits: 
2
ECTS: 
3
Course Language: 
English
Course Coordinator: 
Courses given by: 
Course Objectives: 
The aim of this course is to provide theoretical information about the interactions between the herbal drugs and conventional drugs. The lectures will cover the recent literatures and case-reports concerning the herb-drug interactions. Further, the responsibility of pharmacist for preventing these interactions will also be discussed in detail.
Course Content: 

Recent papers and case-reports reporting the interaction of frequently used herbal drugs in Phytotherapy with conventional drugs will be compiled and discussed.

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study
Course Evaluation Methods: 
A:Written exam, B: multiple chose , C:Filing the blank D:False and troth, E: Oral Exam F: Portfolio, G: Contrabution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Teaching Methods

Assessment Methods

1) Knows the importance of herb-drug interactions. Knows the mechanisms of herb drug interactions

1,2,3

A,C

2) Knows how to prevent herb drug interactions and takes responsibilities

1,2,3

A,C

3) Defines the quality standards in herbal preparations

1,2,3

A,C

4) Knows the effects of herbs such as Hypericum perforatum, Ginkgo biloba, Panax ginseng, Echinacae, garlic as well as their interactions with the prescribed drugs.

1,2,3

A,C

5) Knows how to find scientific papers about the interaction of herbal teas, grape fruit juice, vitamins and minerals with the conventional drugs as well as the herb-drug interactions in oncology and surgery. Has the ability to review these data and present it.

1,2,3

A,C,H

 

Course Flow

Week

Topics

Study Materials

1

  Introduction to herbal drugs, problems with herbal drugs

Lecture notes

2

Methods used for the evaluation of herb-drug interaction, mechanisms of  herb-drug interactions, advers effects of herbal drugs

Lecture notes

3

Mechanisms of drug- drug and herb drug interactions Cytochrome P450 enzyme family

Lecture notes

4

SAINT JOHN'S WORT: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

5

GINKGO and GINSENG: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

6

Echinacea and devil’s claw: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

7

Garlic and flaxseed: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

8

Saw Palmetto and Kava: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

9

Valerian, milk thistle, feverfew: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

10

Black Cohosh, licorice: Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

11

Possible side effects and herb drug interactions of anthraquinone-containing drugs such as senna, buchthorn

Lecture notes

12

Chaste tree, ispaghula seed:   Chemical composition, drug interactions, possible mechanism of interactions and results of interaction

Lecture notes

13

Interactions of  grapefruit juice with conventional drugs

Literature survey and review

14

Interactions of  herbal teas with conventional drugs

Literature survey and review

15

Herb-drug interactions in oncology and in surgery

Literature survey and review

16

Interactions of vitamins and minerals with conventional drugs

Literature survey and review

 

Recommended Sources

Textbook

 

Additional Resources

Elecronic data base: Web of Science, PubMed, Scopus

 

 

Material Sharing

Documents

Lecture notes via COADSYS/MOODLE  

Assignments

Relevant papers

Exams

 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Mid-terms

1

50

Assignment

1

50

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

50

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

50

Total

 

100

 

Course’s Contribution to Program

No

Program Learning Outcomes

Contribution

1

2

3

4

5

1

Acquire skills needed to practice the profession of pharmacy in either a Turkish or an English language setting.

   

X

   

2

Being equipped to access current theoretical and applied knowledge, keeping abreast of new developments, and possessing the critical faculties enabling an accurate and reliable interpretation and assessment of this information.

     

X

 

3

Having the capacity to apply the skills acquired in the field of pharmaceutical science. Possessing the ability to harness his/her acquired knowledge in order to function as a highly accessible health counsellor, providing a ready source of clinically relevant, health-related information to the general public.

     

 

X

4

Keeping abreast of and being equipped to apply the fundamental pharmaceutical and health science principles which guide future developments in modern technology, and being able to share these experiences and skills with colleagues through participatation in professional development education seminars.

     

X

 

5

Knowing how to assess risks arising from the use of drugs and other chemicals and those risks potentially encounterd during laboratory practice.

 

X

 

 

 

6

Acquiring the skills and knowledge needed to interpret findings obtained through quantative and qualitative measurements, and thus reach valid, scientific conclusions based on this data. 

X

   

 

 

7

Being able to compound pharmaceutical products while being knowledgable about their clinical application, interactions, side effects and risks  and apply in proper manner .

 

 

 

X

 

8

Being competent to conduct and manage research and development projects, and share experimental outcomes.

 

 

X

 

 

9

Be competent to accurately and intelligibly communicate clincally relevant information to patients concerning prescription items and other pharmaceutical products.  

     

X

 

10

Being able to function in a multidisciplinary environment. Possessing the skill to collaborate and establish lines of communication with other professionals, while developing their own professional competency through participation in relevant continuing education activities.

     

 

 

11

Being able to play a role in projects which fulfills the profession’s societal responsibilities. Participating in professional activities and undertaking duties in a manner which reflects an awareness of and sensitivity to environmental issues.

   

X

 

 

12

Being capable of opening a community pharmacy, practicing in a hospital pharmacy setting, and offering service in any field related to drugs, cosmetics, medical  and/or plant-derived products. Able to play an active role in his/her own personal professional development, as well as that of colleagues and pharmaceutical students.

       

X

13

Able to play a role in issues related to public health as a member of the health care team while being cognizant of and able to fulfill legal and professional requirements and maintain ethical standards. 

 

X

     

14

Is knowledgable of and equipped to manage the planning, development, compounding and quality control analysis of naturally occuring and synthetic medicines, while also being aware of the processes related to these products’ absorption, distribution, metabolism and excretion from the body.

     

X

 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

16

2

32

Hours for off-the-classroom study (Pre-study, practice)

16

2

32

Mid-terms

1

1

1

Assignment

1

2

2

Final examination

1

1

1

Total Work Load

   

68

Total Work Load / 25 (h)

 

 

2.7

ECTS Credit of the Course

 

 

3