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Course Code: 
PHAR 431
Course Period: 
Autumn
Course Type: 
Core
P: 
3
Lab: 
0
Credits: 
3
ECTS: 
4
Course Language: 
English
Course Objectives: 
A central function of the clinical chemistry laboratory is to provide biochemical information for the management of patients. Such information will be of value only if it is accurate and relevant, and if its significance is appreciated by the clinician so that it can be used appropriately to guide clinical decision-making. These lectures examine how biochemical data are acquired and how they should be used.
Course Content: 

Definitions of clinical biochemistry, regulation of glucose concentration in the body, markers of cardiac injury, metabolism of cholesterol and threeglyceride, mechanisms incolved in the regulation of hormone secretion, enzymes that can be used to detect diseases, tests of liver injury, tests of kidney injury, diagnostically important plasma proteins, Tumor markers, basic tests in hematological disorders, common methods in blood analysis and the parameters of complete blood count.

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study
Course Evaluation Methods: 
A:Written exam, B: multiple chose , C:Filing the blank D:False and troth, E: Oral Exam F: Portfolio, G: Contrabution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Programme learning outcomes

Teaching Methods

Assessment Methods

1.Explains the types of specimens that are routinely and nonroutinely collected for testing and the advantages and disadvantages of each.

1,14

1

A,B,C,D

2.Explains the laboratory procedures involved in assessment of diabetes mellitus in a individual .

1,14

1

A,B,C,D

3.Explains the key markers of cardiac injury and their order of appearance after a myocardial infarction

1,14

1

A,B,C,D

4.Discuss the metabolism of cholesterol and threeglyceride and state the reference interval of each for apparently healtyh subjects.

1,14

1

A,B,C,D

5.Defines physiological functions of hormones and discuss the mechanisms incolved in the regulation of hormone secretion

1,14

1

A,B,C,D

6.Discuss the role of clinical importance of enzymes in the diagnosis and treatment of diseases.

1,14

1

A,B,C,D

7.Discuss common sources of discrepancies in patient liver function, enzyme test results and discuss situations when it is important to communicate bilirubin results to health care providers.

1,14

1

A,B,C,D

8.Discuss the test of kidney injury

1,14

   1

A,B,C,D

9.Learn the abnormalities of diagnostically important plasma proteins, clinical indications for assessment of acute phase proteins and the major clinical use of serum and urine protein electrophoresis.

10. Associate Tumor markers of disease with the organ or tissue location of the disease.

11. Learn common clinical disorders associated with abnormal haemostasis and experience the interpretation of patient results in a variety of clinical settings.

1,14

1

A,B,C,D

12.Describe the cause of anemia and give examples for the test that are used to assess the diagnosis of this disease.

 

1

A,B,C,D

 
 

Course Flow

Week

Teorical Topics                                     

 

Study Materials

1

 Introduction to Clinical Biochemistry

 

Textbook by Prof.Dr. Serdar Öztezcan

2

Carbohyrates in clinical biochemistry

 

Textbook by Prof.Dr Serdar Öztezcan

3

Heart Diseases and Cardiac Markers

 

Textbook by Prof.Dr. Serdar Öztezcan

4

Lipids and Lipoproteins

 

Textbook by Prof.Dr. Serdar Öztezcan

5

Hormones in clinical biochemistry

 

Textbook by Prof.Dr. Serdar Öztezcan

6

Clinical Enzymology

 

Textbook by Assoc.Prof.Dr. Jale Çoban

7

Liver function tests

 

Textbook by Assoc.Prof.Dr. Jale Çoban

8

Renal function tests

 

Textbook by Assoc.Prof.Dr. Jale Çoban

9

Spesicic Proteins

 

Textbook by Assoc.Prof.Dr. Jale Çoban

10

Tumor markers

 

Textbook by Assoc.Prof.Dr. Jale Çoban

11

Coagulation and Fibrinolysis

 

Textbook by Assoc.Prof.Dr. Jale Çoban

12

Hematology and Complete Blood Count test

 

Textbook by Assoc.Prof.Dr. Jale Çoban

13

Case Studies- group Work

 

 

14

Take home work: Case solutions

 

 
 
 

Recommended Sources

Textbook

Prof.Dr. Serdar Öztezcan’s and Assoc.Prof.Dr.Jale Çoban’s cours  note’s prepared for Yeditepe University Faculty of Pharmacy Students

Additional Resources

1.Harper’s Illustrated Bichemistry,R.K.Murray, D.A.Bender, K.M.Botham, V.W.Rodwell, P.A. Weil,McGrawHill, 2009

2.Lippincot’s Illustrated Reviews, Biochemistry, P.C. Champ, R.A.Harvey, D,R, Ferrier, LWW, 2008

3.  Henry’s Clinical Diagnosis and Management by Laboratory Methods

 
 

Material Sharing

Documents

Course note’s by Prof.Dr.Serdar Öztezcan’s and Assoc.Prof.Dr. Jale Çoban ‘s prepared for Yeditepe University Faculty of Pharmacy Students

Assignments

None

Exams

A midterm exam, final exam and make-up exam for failing students

 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Midterm  Exam

1

40

Final Exam

1

60

Make-up Exam for students failing by the end of Final Exam

1

60

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

60

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

40

Total

 

100

 

 

COURSE CATEGORY

Compulsary

 
 

Course’s Contribution to Program

No

Program Learning Outcomes

Contribution

1

2

3

4

5

1

Acquire skills needed to practice the profession of pharmacy in either a Turkish or an English language setting.

         

2

Being equipped to access current theoretical and applied knowledge, keeping abreast of new developments, and possessing the critical faculties enabling an accurate and reliable interpretation and assessment of this information.

   

 

 

 

3

Having the capacity to apply the skills acquired in the field of pharmaceutical science. Possessing the ability to harness his/her acquired knowledge in order to function as a highly accessible health counsellor, providing a ready source of clinically relevant, health-related information to the general public.

   

x

 

 

4

Keeping abreast of and being equipped to apply the fundamental pharmaceutical and health science principles which guide future developments in modern technology, and being able to share these experiences and skills with colleagues through participatation in professional development education seminars.

   

 

   

5

Knowing how to assess risks arising from the use of drugs and other chemicals and those risks potentially encounterd during laboratory practice.

         

6

Acquiring the skills and knowledge needed to interpret findings obtained through quantative and qualitative measurements, and thus reach valid, scientific conclusions based on this data. 

         

7

Being able to compound pharmaceutical products while being knowledgable about their clinical application, interactions, side effects and risks  and apply in proper manner .

         

8

Being competent to conduct and manage research and development projects, and share experimental outcomes.

         

9

Be competent to accurately and intelligibly communicate clincally relevant information to patients concerning prescription items and other pharmaceutical products.  

         

10

Being able to function in a multidisciplinary environment. Possessing the skill to collaborate and establish lines of communication with other professionals, while developing their own professional competency through participation in relevant continuing education activities.

   

x

   

11

Being able to play a role in projects which fulfills the profession’s societal responsibilities. Participating in professional activities and undertaking duties in a manner which reflects an awareness of and sensitivity to environmental issues.

         

12

Being capable of opening a community pharmacy, practicing in a hospital pharmacy setting, and offering service in any field related to drugs, cosmetics, medical  and/or plant-derived products. Able to play an active role in his/her own personal professional development, as well as that of colleagues and pharmaceutical students.

         

13

Able to play a role in issues related to public health as a member of the health care team while being cognizant of and able to fulfill legal and professional requirements and maintain ethical standards. 

   

x

   

14

Is knowledgable of and equipped to manage the planning, development, compounding and quality control analysis of naturally occuring and synthetic medicines, while also being aware of the processes related to these products’ absorption, distribution, metabolism and excretion from the body.

         
 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week: 16x Total course hours)

12

2

24

Hours for off-the-classroom study (Pre-study, practice)

16

3

48

Midterm Exams

1

5

5

Lab. Applications

 

   

Hours for off-the-Lab. study (Pre-study, practice)

 

   

Lab. Midterm Exem

     

Lab. Final

     

Homework

 

 

 

Final

1

   

Total Work Load

 

 

111

Total Work Load / 25 (h)

 

 

4,04

ECTS Credit of the Course

 

 

4