a) Therotical part:
The lectures will cover the secondary metabolites mainly, terpenoids, steroids and alkaloids. Moreover, the knowledge about Marine Pharmacognosy and vitamins and minerals will also be provided.
b) Laboratory applications:
Some assays for the qualitative and quantitative analysis of essential oils, fixed oil, saponins and alkaloids in herbal drugs will be implemented
Vertical Tabs
Course Learning Outcomes
|
Learning Outcomes |
Programme Learning Outcomes |
Teaching Methods |
Assessment Methods |
|
1) Describes the terpenic and steroidal compounds of natural origin |
1 |
1,2,3 |
A,C |
|
2) Defines the term “essential oil” Knows the use of essential oil bearing medicinal and aromatic plants. |
1,2,6 |
1,2,3,7 |
A,C |
|
3) Defines the terms “Iridoid, sesquiterpene, diterpene and saponin” and lists the important medicinal plants containig these metabolites. |
1,2 |
1,2,3,7 |
A,C |
|
4) Defines the plant originated compounds used for the semisynthesis of steroidal drugs. |
1, 2 |
1,2,3,7 |
A,C |
|
5) Knows the effects of cardiac glycosides, their mechanisms of action as well as plants containing cardiac glycosides. |
1,2 |
1,2,3,7 |
A,C |
|
6) Defines the term “alkaloid”. Knows the significance of drug substances of alkaloid origin. |
1 |
1,2,3 |
A,C |
|
7) Defines the extraction, characterization and biological activities of alkaloids. Knows the alkaloid containing medicinal and toxic plants. |
1 |
1,2,3,7 |
A,C |
|
8) Knows the steps for drug discovery from natural sources |
1 |
1,2,3,4 |
A,C,H |
|
9) Knows how to access the recent scientific knowledge about Pharmacognosy and natural products as well as how to interpret, review and present these data. |
1,2,5,7,8 |
1,2,3,4 |
G,H |
Course Flow
|
COURSE CONTENT |
||||
|
Week |
Teorical Topics |
Lab content |
Study Materials |
|
|
1 |
INTRODUCTION TO TERPENOIDS AND STEROIDS BIOSYNTHESIS OF TERPENES AND THEIR PRECURSORS MONOTERPENE AND SESQUITERPENE LACTONE CONTAINING PLANTS |
DEMONSTRATION |
||
|
2 |
ESSENTIAL OILS, CHEMICAL COMPOSITION OF ESSENTIAL OILS METHODS USED FOR THE ISOLATION OF ESSENTIAL OILS |
QUANTATIVE ANALYSIS OF THE FIXED OILS IN VEGETABLE DRUGS DETERMINATION OF PHYSICOCHEMICAL CHARACTERISTICS OF FIXED OILS |
||
|
3 |
LAMIACEAE, ASTERACEAE AND RUTACEAE PLANTS CONTAINING ESSENTIAL OILS OTHER PLANTS CONTAINING ESSENTIAL OILS OLEORESINS AND BALSAMS |
ACID AND SAPONIFICATION VALUES FOR FIXED OILS |
||
|
4 |
IRIDOIDS AND IRIDOID CONTAINING PLANTS DITERPENES, IMPORTANT DITERPENES AND THEIR SOURCES |
DETERMINATION OF ESSENTIAL OILS IN VEGETABLE DRUGS DETERMINATION OF TOTAL PHENOL CONTENT IN ORIGANI OIL |
||
|
5 |
TRITERPENES AND STEROIDS SAPONINS AND SAPONIN CONTAINING PLANTS |
QUANTATIVE ANALYSIS OF TOTAL ALDEHYDE CONTENT IN LEMON OIL |
||
|
6 |
CARDIAC GLYCOSIDES, PHARMACOLOGICAL EFFECTS AND MECHANISMS OF ACTIONS CARDIAC GLYCOSIDES CONTAINING MEDICINAL AND TOXIC PLANTS |
EXTRACTION OF AESCIN FROM THE SEEDS OF AESCULUS HIPPOCASTANUM DETERMINATION OF FOAMING INDEX FOR LIQUIRITIAE RADIX |
||
|
7 |
OTHER STEROIDS AND TRITERPENES CAROTENOIDS AND CAROTENOID CONTAINING PLANTS |
DEMONSTRASYON |
||
|
8 |
ALKALOIDS: DEFINITION, CLASSIFICATION, EXTRACTION AND CHARACTERIZATION, BIOSYNTHESIS AND BIOLOGICAL ACTIVITIES |
DETERMINATION OF ROSMARINIC ACID CONTENT IN CERTAIN LAMIACEAE SPECIES BY HPTLC-DENSITOMETRY |
||
|
9 |
TROPANE AND PYRROLIZIDINE ALKOLOIDS |
MIDTERM |
||
|
10 |
QUINOLIZIDINE AND PIPERIDINE ALKALOIDS ALKALOIDS DERIVATED FROM PHENYLALANINE AND TYROSINE |
EXTRACTION OF CAFFEINE FROM TEA LEAVES |
||
|
11 |
ISOQUINOLINE ALKALOIDS, MONOTERPENOID INDOLE ALKALOIDS, b-CARBOLINE ALKALOIDS |
IDENTIFICATION REACTION FOR CAFFEINE AND PHARMACOPOEIA ANALYSIS OF CAFFEINE |
||
|
12 |
ERGOLINE ALKALOIDS, IMIDAZOLE ALKALOIDS |
QUANTATIVE ANALYSIS OF TROPANE ALKALOID CONTENT IN BELLADONNA LEAVES |
||
|
13 |
TERPENOID ALKALOIDS PURINE BASES DRUG DISCOVERY FROM NATURAL SORUCES |
QUANTATIVE ANALYSIS OF TOTAL ALKALOID CONTENT IN CINCHONA BARK |
||
|
14 |
STUDENT PRESENTATIONS |
MAKE-UP |
||
|
15 |
STUDENT PRESENTATIONS |
|
||
|
16 |
STUDENT PRESENTATIONS |
|
|
|
Recommended Sources
|
RECOMMENDED SOURCES |
|
|
Textbook |
Bruneton, Jean (1999) Pharmacognosy, Phytochemistry, Medicinal Plants (2. Edition) Springer-Verlag |
|
Additional Resources |
Evans, W.C., (2009) Trease and Evans Pharmacognosy, Saunders Elsevier (16th edition) |
Material Sharing
|
MATERIAL SHARING |
|
|
Documents |
Lecture notes (Prof. Dr. Hasan Kırmızıbekmez) |
|
Assignments |
Relevant papers and textbooks |
|
Exams |
|
Assessment
|
ASSESSMENT |
||
|
IN-TERM STUDIES |
NUMBER |
PERCENTAGE |
|
Midterm Exam |
2 |
55 |
|
Short Exam |
||
|
Lab. (Assignment) |
1 |
15 |
|
Lab.Final |
1 |
30 |
|
Total |
|
100 |
|
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE |
|
40 |
|
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE |
|
60 |
|
Total |
|
100 |
|
COURSE CATEGORY |
Compulsary |
Course’s Contribution to Program
|
COURSE'S CONTRIBUTION TO PROGRAM |
|||||||
|
No |
Program Learning Outcomes |
Contribution |
|||||
|
1 |
2 |
3 |
4 |
5 |
|||
|
1 |
Has national and international up-to-date, theoretical and applied knowledge in the field of pharmacy. |
x |
|||||
|
2 |
Defines problems related to the profession, collects data, evaluates its accuracy and reliability, develops evidence-based solutions, shares them with healthcare professionals, makes necessary explanations to other people. |
x |
|||||
|
3 |
Communicates accurately and effectively in accordance with cultural and ethical values with all relevant professional groups, especially those working in the field of health, and all segments of society, using information and communication technologies. |
x |
|||||
|
4 |
Takes into account the law and ethics when dealing with public health issues. |
x |
|||||
|
5 |
Acts as a pharmacist with high career awareness, self-confidence, leadership spirit, who is prone to teamwork, entrepreneurial, productive and able to manage financial resources. |
x |
|||||
|
6 |
Based on the principle of pharmaceutical care, Acts as an easily accessible health consultant with a patient-oriented approach and plays an active role in constantly informing the society. |
x |
|||||
|
7 |
Improves his/her knowledge by participating in in-service training and activities in line with the needs of the century and society, takes part in the professional development of colleagues and adopts the lifelong learning principle. |
x |
|||||
|
8 |
Suggests and manages multidisciplinary / interdisciplinary research and development projects related to pharmaceuticals, cosmetics, medical devices and shares their results. |
x |
|||||
|
9 |
Applies knowledge and skills for the benefits of the society taking part in social responsibility projects. |
x |
|||||
|
10 |
Fulfills the requirements of quality management systems using the theoretical and applied knowledge acquired in the field. |
x |
|||||
ECTS
|
ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION |
|||
|
Activities |
Quantity |
Duration |
Total |
|
Course Duration (Including the exam week: 16x Total course hours) |
16 |
4 |
64 |
|
Hours for off-the-classroom study (Pre-study, practice) |
16 |
1 |
16 |
|
Midterm Exams |
2 |
1 |
2 |
|
Lab. Applications |
16 |
4 |
64 |
|
Hours for off-the-Lab. study (Pre-study, practice) |
16 |
1 |
16 |
|
Lab. Midterm Exam |
1 |
1 |
1 |
|
Lab. Final |
1 |
1 |
1 |
|
Homework (Assignment) |
1 |
5 |
5 |
|
Final |
1 |
2 |
2 |
|
Total Work Load |
|
|
171 |
|
Total Work Load / 25 (h) |
|
|
6.8 |
|
ECTS Credit of the Course |
|
|
7 |