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Course Code: 
PHAR 582
Course Type: 
Elective
P: 
2
Lab: 
0
Credits: 
2
ECTS: 
3
Course Language: 
English
Course Objectives: 
Drug pharmacokinetics and pharmacodynamics are affected by the genetic makeup of an individuals. The aim of this course is to make the students aware how individual’s genetic variation determines his or her response to drugs.
Course Content: 

a) Theory: Development of the concept of pharmacogenomics, related basic genetic information, variations on the genes related to drug metabolizing enzymes, drug transporters & drug target proteins (receptors), clinical applications in different pharmacological class and individualization of therapy, and regulatory, ethical, legal, & social aspects.

b)Laboratory applications/Practical: ---

Course Methodology: 
1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study
Course Evaluation Methods: 
A:Written exam, B: multiple chose , C:Filing the blank D:False and troth, E: Oral Exam F: Portfolio, G: Contrabution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes

Programme Learning Outcomes*

Teaching Methods**

Assessment Methods***

Students’ ability to

1) explain the basic genetic concepts related to  pharmacogenomics.

1, ÖÇ2

1, 2, 3, 4

B, H

2) explains effect of genetic variations on the pharmacokinetics and pharmacodynamics of drugs.

1, 2, 6

1, 2, 3, 4

B, H

3) develop rational drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects.

1, 2, 3  

1, 2, 3, 4

B, H

4) optimize therapy for each individual's unique genetic makeup (personalized medicine).

1, 2, 9, 12

1, 2, 3, 4

B, H

5) explain regulatory, ethical, legal, & social aspects of pharmacogenomics

1, 2, 3, 11, 13

1, 2, 3, 4

B, H

 
 

Course Flow

Week

Theorical Topics                                      

Lab content

Study Materials

1

Genetic Concepts of Pharmacogenomics: Basic Review of DNA, Genes, Polymorphisms, Haplotypes and Nomenclature

---

---

2

Analytical Methods to Identify Genetic Variations and Bioinformatics

---

---

3

Developing Perspectives on Pharmacogenomics

---

---

4

Pharmacogenetics of Cytochrome P450 and Phase II Drug-Metabolizing Enzymes, Nongenetic Influences on Drug Metabolism

---

---

5

Pharmacogenetics of Drug Transporters

---

---

6

Assessment of Economic Impact of Pharmacogenomic Testing

---

---

7

Regulatory , Ethical, Legal, and Social Considerations in Pharmacogenomics

---

---

8

Clinical Application: Cardiovascular Pharmacogenomics

---

---

9

Clinical Application: Pharmacogenomics for Infectious Diseases

---

---

10

Clinical Application: Pharmacogenomics in Oncology

---

---

11

Clinical Application: Psychiatry and Addiction Medicine

---

---

12

Clinical Application: Immunology, Transplantation, and Vaccines

---

---

13

Clinical Application: Pharmacogenomics in Neurology

---

---

14

Clinical Application: Pharmacogenomics of Gastrointestinal Drugs- Focus on Proton Pump Inhibitors

---

---

15

Clinical Application: Genomics and the Kidney

---

---

 
 

Recommended Sources

Textbook

1. Joseph S. Bertino Jr., C. Lindsay DeVane, Uwe Fuhr, Angela D. M. Kashuba, Joseph D. Ma. Pharmacogenomics: An Introduction and Clinical Perspective, cGraw-Hill Education, USA, 2013.

2. Martin M. Zdanowicz. Concepts in Pharmacogenomics. American Society of Health-System Pharmacist Inc., USA, 2010.

3. Werner Kalow, Urs A. Meyer, Rachel F. Tyndale. Pharmacogenomics, Taylor & Francis Group, LLC, USA, 2005.

4. Julio Licinio, Ma-Li Wang. Pharmacogenomics- The Search for Individualized Therapy, Wiley-VCH, verlag GmbH, Germany, 2002.

Additional Resources

 

 
 

Material Sharing

Documents

Power point presentarions

Assignments

---

Exams

---

 
 

Assessment

IN-TERM STUDIES

NUMBER

PERCENTAGE

Midterm  Exam

1

50

Quizzes

---

---

assignment

1

50

Total

 

100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

 

50

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

 

50

Total

 

100

 

 

COURSE CATEGORY

Elective

 
 

Course’s Contribution to Program

No

Program Learning Outcomes (ÖÇ)

Contribution*

1

2

3

4

5

1

Acquire skills needed to practice the profession of pharmacy in either a Turkish or an English language setting.

     

X

 

2

Being equipped to access current theoretical and applied knowledge, keeping abreast of new developments, and possessing the critical faculties enabling an accurate and reliable interpretation and assessment of this information.

     

X

 

3

Having the capacity to apply the skills acquired in the field of pharmaceutical science. Possessing the ability to harness his/her acquired knowledge in order to function as a highly accessible health counsellor, providing a ready source of clinically relevant, health-related information to the general public.

   

X

   

4

Keeping abreast of and being equipped to apply the fundamental pharmaceutical and health science principles which guide future developments in modern technology, and being able to share these experiences and skills with colleagues through participatation in professional development education seminars.

   

X

   

5

Knowing how to assess risks arising from the use of drugs and other chemicals and those risks potentially encounterd during laboratory practice.

X

       

6

Acquiring the skills and knowledge needed to interpret findings obtained through quantative and qualitative measurements, and thus reach valid, scientific conclusions based on this data. 

   

X

   

7

Being able to compound pharmaceutical products while being knowledgable about their clinical application, interactions, side effects and risks  and apply in proper manner.

X

       

8

Being competent to conduct and manage research and development projects, and share experimental outcomes.

 

X

     

9

Be competent to accurately and intelligibly communicate clincally relevant information to patients concerning prescription items and other pharmaceutical products.  

   

X

   

10

Being able to function in a multidisciplinary environment. Possessing the skill to collaborate and establish lines of communication with other professionals, while developing their own professional competency through participation in relevant continuing education activities.

X

       

11

Being able to play a role in projects which fulfills the profession’s societal responsibilities. Participating in professional activities and undertaking duties in a manner which reflects an awareness of and sensitivity to environmental issues.

   

X

   

12

Being capable of opening a community pharmacy, practicing in a hospital pharmacy setting, and offering service in any field related to drugs, cosmetics, medical  and/or plant-derived products. Able to play an active role in his/her own personal professional development, as well as that of colleagues and pharmaceutical students.

   

X

   

13

Able to play a role in issues related to public health as a member of the health care team while being cognizant of and able to fulfill legal and professional requirements and maintain ethical standards. 

   

X

   

14

Is knowledgable of and equipped to manage the planning, development, compounding and quality control analysis of naturally occuring and synthetic medicines, while also being aware of the processes related to these products’ absorption, distribution, metabolism and excretion from the body.

X

       
 
 

ECTS

Activities

Quantity

Duration
(Hour)

Total
Workload
(Hour)

Course Duration (Including the exam week)

16

2

32

Hours for off-the-classroom study (Pre-study, practice)

16

2

32

Midterm Examination

1

1

1

Lab. Applications

---

---

---

Hours for off-the-Lab. study (Pre-study, practice)

---

---

---

Lab. Midterm Examination

---

---

---

Lab. Final

---

---

---

Homework/Assignment

1

10

10

Final  Examination

1

1

1

Total Work Load

 

 

76

Total Work Load / 25 (h)

 

 

3.04

ECTS Credit of the Course

 

 

3