Pharmacogenomics

Course Code:

PHAR 582

Course Type:

Elective

P:

2

Lab:

0

Credits:

2

ECTS:

3

Course Language:

English

Course Objectives:

Drug pharmacokinetics and pharmacodynamics are affected by the genetic makeup of an individuals. The aim of this course is to make the students aware how individual’s genetic variation determines his or her response to drugs.

Course Content:

a) Theory

Development of the concept of pharmacogenomics, related basic genetic information; variations on the genes related to drug metabolizing enzymes, drug transporters & drug target proteins (receptors); pharmacogenomic information on different pharmacological class of drugs & individualization of therapy; and regulatory, ethical, legal, & social aspects.

b) Laboratory applications/Practical ---

Course Methodology:

1: Lecture, 2: Question-Answer, 3: Discussion, 4: Presentation, 5:Simulation, 6: Video, 7: Applications, 8:Case Study

Course Evaluation Methods:

A:Written exam, B: multiple choice , C:Filing in the blank D:True False, E: Oral Exam F: Portfolio, G: Contribution of course activities H:Homework

Vertical Tabs

Course Learning Outcomes

Learning Outcomes	Programme Learning Outcomes	Teaching Methods	Assessment Methods
Students’ ability to 1) explain the basic genetic concepts related to pharmacogenomics.	1-7	1-4	B, C, D, G, H
2) explains the effects of genetic variations on the pharmacokinetics and pharmacodynamics of drugs.	1-7	1-4	B, C, D, G, H
3) develop rational drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects.	1-7	1-4	B, C, D, G, H
4) optimize therapy for each individual's unique genetic makeup (personalized medicine).	1-7	1-4	B, C, D, G, H
5) explain regulatory, ethical, legal, & social aspects of pharmacogenomics	1-7	1-4	B, C, D, G, H

Course Flow

COURSE CONTENT (Weekly Detailed Course Content)
Week	Theoretical Topics	Lab content	Study Materials
1	Genetic Concepts of Pharmacogenomics (PGx): Basic Review of DNA, Genes, Polymorphisms, Haplotypes and Nomenclature, Developing Perspectives on PGx	---	---
2	Analytical Methods to Identify Genetic Variations and Bioinformatics	---	---
3	Pharmacogenetics of Cytochrome P450 and Phase II Drug-Metabolizing Enzymes, Nongenetic Influences on Drug Metabolism	---	---
4	Pharmacogenetics of Drug Transporters	---	---
5	Assessment of Economic Impact of Pharmacogenomic Testing	---	---
6	Regulatory , Ethical, Legal, and Social Considerations in Pharmacogenomics	---	---
7	Cardiovascular PGx	---	---
8	PGx for Infectious Diseases	---	---
9	PGx in Oncology	---	---
10	PGx of Psychiatry and Addiction Medicine	---	---
11	PGx of Immunology, Transplantation, and Vaccines	---	---
12	PGx in Neurology	---	---
13	PGx of Gastrointestinal Drugs- Focus on Proton Pump Inhibitors	---	---
14	Genomics and the Kidney	---	---

Recommended Sources

RECOMMENDED SOURCES

Textbook

1. Joseph S. Bertino Jr., C. Lindsay DeVane, Uwe Fuhr, Angela D. M. Kashuba, Joseph D. Ma. Pharmacogenomics: An Introduction and Clinical Perspective, McGraw-Hill Education, USA, 2013.

2. Martin M. Zdanowicz. Concepts in Pharmacogenomics. American Society of Health-System Pharmacist Inc., USA, 2010.

3. Werner Kalow, Urs A. Meyer, Rachel F. Tyndale. Pharmacogenomics, Taylor & Francis Group, LLC, USA, 2005.

4. Julio Licinio, Ma-Li Wang. Pharmacogenomics- The Search for Individualized Therapy, Wiley-VCH, verlag GmbH, Germany, 2002.

Additional Resources

Material Sharing

MATERIAL SHARING
Documents	Powerpoint presentations
Assignments	---
Exams	---

Assessment

ASSESSMENT
IN-TERM STUDIES	NUMBER	PERCENTAGE
Midterm Exam	1	50
Quizzes	---	---
assignment	1	50
Total		100
CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE		50
CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE		50
Total		100

COURSE CATEGORY

Elective

Course’s Contribution to Program

COURSE'S CONTRIBUTION TO PROGRAM
No	Program Learning Outcomes	Contribution
No	Program Learning Outcomes	1	2	3	4	5
1	Has national and international up-to-date, theoretical and applied knowledge in the field of pharmacy.					X
2	Defines problems related to the profession, collects data, evaluates its accuracy and reliability, develops evidence-based solutions, shares them with healthcare professionals, makes necessary explanations to other people.				X
3	Communicates accurately and effectively in accordance with cultural and ethical values with all relevant professional groups, especially those working in the field of health, and all segments of society, using information and communication technologies.				X
4	Takes into account the law and ethics when dealing with public health issues.			X
5	Acts as a pharmacist with high career awareness, self-confidence, leadership spirit, who is prone to teamwork, entrepreneurial, productive and able to manage financial resources.			X
6	Based on the principle of pharmaceutical care, acts as an easily accessible health consultant with a patient-oriented approach and plays an active role in constantly informing the society.				X
7	Improves his/her knowledge by participating in in-service training and activities in line with the needs of the century and society, takes part in the professional development of colleagues and adopts the lifelong learning principle.				X
8	Suggests and manages multidisciplinary / interdisciplinary research and development projects related to pharmaceuticals, cosmetics, medical devices and shares their results.		X
9	Applies knowledge and skills for the benefits of the society taking part in social responsibility projects.		X
10	Fulfills the requirements of quality management systems using the theoretical and applied knowledge acquired in the field.		X

ECTS

ECTS BASED ON STUDENT WORKLOAD
Activities	Quantity	Duration (Hour)	Total Workload (Hour)
Course Duration (Including the exam week)	14	2	28
Hours for off-the-classroom study (Pre-study, practice)	14	2	28
Midterm Examination	1	1	1
Lab. Applications	---	---	---
Hours for off-the-Lab. study (Pre-study, practice)	---	---	---
Lab. Midterm Examination	---	---	---
Lab. Final	---	---	---
Homework/Assignment	1	10	10
Final Examination	1	1	1
Total Work Load			68
Total Work Load / 25 (h)			2.72
ECTS Credit of the Course			3

Search form