Hasan KIRMIZIBEKMEZ

Position:

Vice Dean

Telephone:

02165780000-3050

Office:

C-651

E-posta:

hkirmizibekmez@yeditepe.edu.tr

Çalışma Türü:

Tam Zamanlı

Akademik

Resume

Research Interest

Isolation and structure elucidation of natural products from medicinal plants
Pharmacognosy – Phytochemistry
Bioactive natural products
Iridoids, phenylethanoids, flavonoids, cardiac glycosides, saponins

Biography

BA: Hacettepe University,1997

MS: Hacettepe University, Pharmacognosy, 1999

PhD: Hacettepe University, Pharmacognosy, 2002

Courses Given

Pharmacognosy I+Lab.I

Graduation Project I

Pharmacognosy II+Lab.II

Graduation Project II

Publications

Papers

Gökmen A, Kúsz N, Karaca N, Demirci F, Hohmann J, Kırmızıbekmez H. (2020) Secondary metabolites from Verbascum bugulifolium Lam. and their bioactivities. Nat Prod Res, in press. doi: 10.1080/14786419.2020.1753052
Aru B, Güzelmeric E, Akgül A, Yanıkkaya Demirel G, Kırmızıbekmez H. (2019) Antiproliferative activity of chemically characterized propolis from Turkey and its mechanisms of action. Chem Biodivers, 16 (7): e1900189.
Kırmızıbekmez H, Erdoğan M, Kúsz N, Karaca N, Erdem U, Demirci F, Hohmann J. (2019) Secondary metabolites from the aerial parts of Sideritis germanicopolitana and their in vitro enzyme inhibitory activities. Nat Prod Res, in press. https://doi.org/10.1080/14786419.2019.1586700.
Bardakci H, Celep E, Gözet T, Kan Y, Kırmızıbekmez H. (2019) Phytochemical characterization and antioxidant activities of the fruit extracts of several Crataegus taxa. S. Afr. J. Boty, 124: 5-13.
Çevik D, Kan Y, Kırmızıbekmez H. (2019) Mechanisms of action of cytotoxic phenolic compounds from Glycyrrhiza iconica roots, Phytomedicine, 58: 152872.
Matsa M, Bardakci H, Gousiadou C, Kırmızıbekmez H, Skaltsa H. (2019) Secondary metabolites from Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet. Biochem Syst Ecol, 83: 71-76.
Kırmızıbekmez H, İnan Y, Reis R, Sipahi H, Gören AC, Yeşilada E. (2019) Phenolic compounds from the aerial parts of Clematis viticella L. and their in vitro anti-inflammatory activities. Nat Prod Res, 33(17): 2541-2544.
Çevik D, Burçin Yılmazgöz Ş, Kan Y, Akhan Güzelcan E, Durmaz I, Çetin-Atalay R, Kırmızıbekmez H. (2018) Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action. Ind Crop Prod,124: 389-396.
Kırmızıbekmez H, Kúsz N, Bérdi P, Zupkó I, Hohmann J. (2018) New iridoids from the roots of Valeriana dioscoridis Sm. Fitoterapia, 130: 73-78.
Atay Balkan İ, Doğan HT, Zengin G, Çolak N, Ayaz FA, Gören AC, Kırmızıbekmez H, Yeşilada E. (2018) Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components, Ind Crop Prod, 112: 24-31.
Renda G, Korkmaz B, Kılıç M, Duman MK, Kırmızıbekmez H. (2018) Evaluation of in vivo analgesic activity of Scrophularia kotscyhana and isolation of bioactive compounds through activity-guided fractionation. Nat Prod Res, 32: 1902-1910.
Atay Balkan İ, İlter Akülke AZ, Bağatur Y, Telci D, Gören AC, Kırmızıbekmez H, Yesilada E. (2017) Sambulin A and B, non-glycosidic iridoids from Sambucus ebulus, exert significant in vitro anti-inflammatory activity in LPS-induced RAW 264.7 macrophages via inhibition of MAPKs's phosphorylation. J Ethnopharmacol, 206: 347-352.
Kırmızıbekmez, H., Demir, D. “Iridoid Glycosides and Phenolic Compounds from the Flowers of Vitex agnus-castus” Helvetica Chimica Acta, 99, 518-522 (2016).
Atay, İ., Kırmızıbekmez, H., Kaiser, M., Akaydin, G.,Yesilada, E., Tasdemir, D., “Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites” Pharmaceutical Biology, 54, 1808-1814 (2016).
Sipahi, H., Gostner, J.M., Becker, K., Charehsaz, M., Kırmızıbekmez, H., Schennach, H., Aydın, A., Fuchs, D. “Bioactivites of two common polyphenolic compounds: Verbascoside and catechin” Pharmaceutical Biology, 54, 4, 712-719 (2016).
Bardakci, H., Skaltsa, H., Milosevic-Ifantis, T., Lazari, D., Hadjipavlou-Litina, D., Yesilada, E., Kırmızıbekmez, H. “Antioxidant activities of several Scutellaria taxa and bioactive phytoconstituents from Scutellaria hastifolia L.” Industrial Crops and Products, 77, 196-203 (2015).
Kırmızıbekmez, H., Uysal, G.B., Masullo, M., Demirci, F., Bağcı, Y., Kan, Y., Piacente S. “Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities” Fitoterapia, 103, 289-293 (2015).
Kırmızıbekmez, H. “Phenylethanoid glycosides from Digitalis viridiflora” Records of Natural Products, 9, 369-373 (2015).
Atay, İ., Kırmızıbekmez, H., Gören, A.C., Yeşilada, E. “Secondary metabolites from Sambucus ebulus” Turkish Journal of Chemistry, 39, 34-41 (2015).
Kırmızıbekmez, H., Bardakcı, H., Masullo, M., Kamburoğlu, Ö., Eryılmaz, G., Akaydın, G., Yeşilada, E., Piacente, S. “Flavonol glycosides and iridoids from Asperula lilaciflora” Helvetica Chimica Acta, 97, 1571-1576 (2014).
Sipahi, H., Becker, K., Gostner, J.M., Charehsaz, M., Kırmızıbekmez, H., Schennach, H., Aydin, A., Fuchs, D. “Effects of globularifolin on cell survival, nuclear factor-κB activity, neopterin production, tryptophan breakdown and free radicals in vitro” Fitoterapia, 92, 85–92 (2014).
Kırmızıbekmez, H, Masullo., M, Festa, M., Capasso, A., Piacente, S. “Steroidal Glycosides with Antiproliferative Activities from Digitalis trojana” Phytotheraphy Research, 28, 534–538 (2014).

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